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Content of phospholipid, cerebroside and cerebroside sulfate in the central nervous system of mice with acute experimental viral demyelination

Annanepesov, K.N.; Levitina, M.V.; Sergienko, E.V.

Biulleten' Eksperimental'noi Biologii i Meditsiny 99(1): 33-34

1985

ISSN/ISBN: 0365-9615
PMID: 2981576
Document Number: 246823
A study was made of the content of phospholipids, cerebrosides and cerebroside sulfates in the central nervous system of mice with experimental acute viral encephalomyelitis. No considerable changes in phospholipid content were revealed. A significant drop in the content of cerebrosides and cerebroside sulfates was defected in the CNS, being more pronounced in the spinal cord of sick animals. The reduction in the content of glycolipids can be explained by myelin disintegration and by the effect of viruses on the olygodendrocytes in which cerebrosides and cerebroside sulfates are synthesized.

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