Local and general treatment with ceftazidime as monotherapy in central nervous system infections and in septicemic infection
Fiori, G.P.; Dietz, A.; Montanari, M.; Torre, D.
International Journal of Clinical Pharmacology Therapy and Toxicology 23(6): 326-328
1985
ISSN/ISBN: 0174-4879 PMID: 3894254 Document Number: 246751
Patients (23, mean age: 47 yr; range: 4 mo. to 79 yr) admitted to Varese Regional Hospital over the period from Oct. 1983 to March 1984 and suffering from severe infections of a septicemic nature were treated with ceftazidime. All patients had previously received other broad-spectrum antibacterial agents. Isolation of causative pathogens and evaluation of their susceptibility to ceftazidime justified use of the drug as monotherapy. Ceftazidime was administered i.v. at the mean dose of 60-120 mg/kg per day. In some cases, it was injected directly into the renal parenchyma (2 g/day) or into the cerebral ventricles (1 mg/kg per day). Local and systemic tolerance were optimal in all cases, no significant side effects being observed. Eradication of pathogens was excellent and clinical outcome satisfactory in all patients.