Single-dose pharmacokinetic study of 13-cis-retinoic acid in man
Besner, J.G.; Leclaire, R.; Band, P.; Meloche, S.; Deschamps, M.; Mailhot, S.; Moisan, R.; Diorio, G.
Cancer Treatment Reports 69(3): 275-277
1985
ISSN/ISBN: 0361-5960 PMID: 3856478 Document Number: 246228
A pharmacokinetic study of 13-cis-retinoic acid was performed in nine patients following administration of a single oral dose of 80 mg. An average lag time of 1.2 hours was observed, followed by fast absorption, with a mean half-life of 0.5 hour. Peak plasmatic concentration of 733 ng/ml occurred at 2.3 hours. The disposition profile showed a rapid distribution half-life of 1.3 hours and a terminal elimination half-life of 24.7 hours. No 13-cis-retinoic acid was detected unchanged in urine. An important interpatient variability was noted.