Trazodone, a nontricyclic antidepressant, is an inhibitor of adenosine deaminase
Sheid, B.
Research Communications in Chemical Pathology and Pharmacology 47(1): 149-152
1985
ISSN/ISBN: 0034-5164 PMID: 3983468 Document Number: 245981
Trazodone, a nontricyclic antidepressant drug, is a noncompetitive inhibitor of adenosine deaminase. The specific activity of adenosine deaminase in rat brain cortex homogenate is 140 +/- 15 (SEM) nm/min/gm tissue, while the apparent Km of adenosine is 77 microM. The apparent Ki of trazodone for the brain cortex enzyme is 1 X 10(-4)M, and 6 X 10(-5)M for purified calf intestine mucosal enzyme.