Primary dysmenorrhea treatment with a desogestrel-containing low-dose oral contraceptive
Hendrix, S.L.; Alexander, N.J.
Contraception 66(6): 393-399
2002
ISSN/ISBN: 0010-7824 PMID: 12499030 DOI: 10.1016/s0010-7824(02)00414-6Document Number: 245335
This randomized, double-blind, placebo-controlled exploratory study examined the efficacy and safety of a low-dose oral contraceptive (Mircette(R)), desogestrel/ethinyl estradiol (DSG/EE) and ethinyl estradiol (EE)) in relieving the symptoms of dysmenorrhea. Twenty-three clinics in the United States enrolled 77 women (age ltoreq32 years) with primary dysmenorrhea documented for at least four consecutive cycles. Forty participants received DSG/EE&EE and 37 received placebo for four consecutive 28-day cycles. The intensity of menstrual-related distress was measured with the Menstrual Distress Questionnaire (MDQ). Patient diaries were used to assess number of school/work days missed as well as the use of rescue medication. Participants receiving DSG/EE&EE recorded reduced menstrual pain severity, lower total MDQ scores, and significantly less menstrual cramping. No significant change in bloating, anxiety, loneliness, weight gain, or acne was reported. The DSG/EE&EE formulation shows promise for the treatment of primary dysmenorrhea and was well tolerated by the participants in this study.