Embryonic testicular regression syndrome and severe mental retardation in sibs
de Grouchy, J.; Gompel, A.; Salomon-Bernard, Y.; Kuttenn, F.; Yaneva, H.; Paniel, J.B.; Le Merrer, M.; Roubin, M.; Doussau de Bazignan, M.; Turleau, C.
Annales de Genetique 28(3): 154-160
1985
ISSN/ISBN: 0003-3995 PMID: 3879148 Document Number: 244531
The embryonic testicular regression syndrome associated with severe mental retardation is reported in three 46,XY sibs each of whom has a 46,XY chromosome complement. A fourth sib, a sister, also is severely retarded mentally; her chromosome complement is 46,XX. The 46,XY individuals, who were raised as females, presented varying degrees of genital ambiguity, indicating that their gonadal activities had been arrested at different times during embryogenesis. No trace of gonadal tissue could be found in either patient. The coincidence of the embryonic testicular regression syndrome and severe mental retardation in the same sibship is discussed.