Histologic study of venous thrombosis induced in the rat
Doutremepuich, C.; Kuttler, M.C.; Bousquet, F.; Quilichini, R.; De Mascarel, M.; Toulemonde, F.; Vairel, E.G.
Annales Pharmaceutiques Francaises 43(2): 161-164
1985
ISSN/ISBN: 0003-4509 PMID: 4091458 Document Number: 244393
Histological study of venous thrombus, experimentally induced in the rat, shows the analogy of the structure with a human thrombus. The comparative study of sections of thrombus, removed 6 hours after ligaturing inferior vena cava of rat, shows a structural difference between the section of heparinized thrombus and the section of a placebo thrombus. Induced heparin, subcutaneously administered 90 mn after ligature with 1.66 mg/kg dosage, brings about an important recruitment of polymorphonuclear leukocytes within the thrombus.