Methods of suppression of myonephropathic metabolic syndrome
Esato, K.; Nakano, H.; Ohara, M.; Nomura, S.; Mohri, H.
Journal of Cardiovascular Surgery 26(5): 473-478
1985
ISSN/ISBN: 0021-9509 PMID: 4030879 Document Number: 244043
Acute arterial occlusoin of the extremities may result in severe and complex metabolic derangements. In order to investigate therapeutic means of controlling such metabolic derangements, 19 adult mongrel dogs weighing between 7 and 15kg underwent acute arterial occlusion by cross-clamping the infrarenal aorta. Clamping was released after 48 hours. The experimental animals were divided into three groups: (1) an untreated groups, (2) a THAM group, and (3) a perfusion group. Biochemical and electrolyte analyses were measured before and 1 hour after occlusion, and 1, 3, 12, 24, and 48 hours after the release of occlusion. The SGOT, creatinine, CPK, and aldolase levels rose after release of the occlusion and were significantly higher in the untreated group than in the THAM and perfusion groups. Among these enzymatic changes, the CPK level showed the largest increase. The serum potassium levels remained almost at preoccluson levels after release of the occlusion. It was concluded that the intravenous administration of THAM and peripheral washing were effective against untoward metabolic changes occurring in the ischemic extremities.