Endothelial and lesion cell growth patterns of early smooth-muscle cell atherosclerotic lesions in swine
Scott, R.F.; Kim, D.N.; Schmee, J.
Archives of Pathology and Laboratory Medicine 109(5): 450-453
1985
ISSN/ISBN: 0003-9985 PMID: 3838660 Document Number: 243800
This study shows that the endothelial cell turnover over the early porcine atherosclerotic lesion is more or less uniform in distribution. This is contrary to the findings in White Carneau pigeons where the increased endothelial cell turnover has a zonal pattern, being much greater at the lesion edge. The difference in the endothelial cell pattern of turnover in the two lesions probably is a reflection of their different manner of development. The porcine abdominal aortic lesion is derived from naturally occurring preexisting collections of intimal smooth-muscle cells called intimal cell masses. After 90 days of a hyperlipidemic diet these lesions are composed predominantly of smooth-muscle cells, with very few monocytes. The White Carneau pigeon lesion develops from circulating monocytes that have been shown to adhere to the edge of the lesion.