Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda
Gray, R.H.; Wabwire-Mangen, F.; Kigozi, G.; Sewankambo, N.K.; Serwadda, D.; Moulton, L.H.; Quinn, T.C.; O'Brien, K.L.; Meehan, M.; Abramowsky, C.; Robb, M.; Wawer, M.J.
American Journal of Obstetrics and Gynecology 185(5): 1209-1217
2001
ISSN/ISBN: 0002-9378 PMID: 11717659 DOI: 10.1067/mob.2001.118158Document Number: 243332
The effects of sexually transmitted disease (STD) control during pregnancy on maternal and infant health in Rakai District, Uganda are assessed. Decreased incidence of STD (Trichomonas vaginalis, bacterial vaginosis, Neisseria gonorrhoeae, Chlamydia trachomatis and infant ophthalmia) is observed. Significant reductions in neonatal mortality, low birth weight and preterm delivery rates are also noted. Maternal human immunodeficiency virus (HIV) acquisition and maternal HIV transmission remain unchanged. It is concluded that treatment of STD during pregnancy improves maternal and infant health. However, treatment of these infections does not reduce the rates of maternal HIV acquisition or mother-to-infant HIV transmission.