Response to aminoglutethimide after failure of tamoxifen therapy in breast cancer
Sutherland, C.M.; Muchmore, J.H.; Carter, R.D.
Southern Medical Journal 78(8): 987-989
1985
ISSN/ISBN: 0038-4348 PMID: 4023793 Document Number: 242581
A 54-year-old woman had a primary breast cancer with an estrogen receptor of 11.9 fmoles/mg of protein. One year later bony metastases were treated with tamoxifen. The disease progressed rapidly, and therapy was changed to aminoglutethimide, which has resulted in an almost complete remission. This case shows that patients who fail to respond to tamoxifen therapy may have a good response to other endocrine manipulation--in this instance, aminoglutethimide.
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