Neonatal behaviour disturbances in infants of epileptic women treated during pregnancy

Koch, S.; Göpfert-Geyer, I.; Häuser, I.; Hartmann, A.; Jakob, S.; Jäger-Roman, E.; Nau, H.; Rating, D.; Helge, H.; Koch, S; Göpfert-Geyer, I; Häuser, I; Hartmann, A; Jakob, S; Jäger-Roman, E; Nau, H; Rating, D; Helge, H

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Neonatal behaviour disturbances in infants of epileptic women treated during pregnancy

Koch, S.; Göpfert-Geyer, I.; Häuser, I.; Hartmann, A.; Jakob, S.; Jäger-Roman, E.; Nau, H.; Rating, D.; Helge, H.

Progress in Clinical and Biological Research 163b: 453-461

1985

ISSN/ISBN: 0361-7742

PMID: 3983173

Document Number: 242469

Infants exposed in utero to antiepileptic drugs showed significantly more behaviour disturbances such as sedation (p less than 0.05) and hyperexcitability (p less than 0.01) than infants of a control group. The presence of these clinical symptoms and the time of their appearance did not seem to be dependent on the type of maternal medication, nor on the drug serum concentration in cord blood nor on the rate of drug disappearance from the infant's plasma.