Pharmacokinetics of mycophenolic acid in kidney transplant recipients treated with a low dose (1 gram/day) of mycophenolate mofetil
Julasareekul, W.; Eiam-Ong, S.; Bejraputra, O.; Seublinvong, T.
Journal of the Medical Association of Thailand 86(8): 766-771
2003
ISSN/ISBN: 0125-2208 PMID: 12948276 Document Number: 2421
Pharmacokinetic studies of mycophenolic acid (MPA) were performed in 16 stable Thai kidney transplant recipients treated with 1 g/d of mycophenolate mofetil (MMF). The complete area under the blood concentration-time curve (AUC) of MPA was determined using the linear trapezoidal rule from 8 concentrations at, 0, 1, 2, 3, 4, 6, 8, and 12 h after MMF administration. The mean values of AUC0-12 were 37.54+-0.80 mugcntdoth/ml. MPA concentrations at 8 h after dosing, not the trough or maximum levels, showed the best correlation with AUC0-12 (r2=0.72). The equation model of abbreviated AUC of MPA, derived by multiple linear regression analysis, that had the highest correlation (r2) and lowest absolute prediction error (APE) was: AUC=0.6 C1+1.9 C3+8.68 C8+4.65 (r2=0.92, APE=2.05+-0.32%). The best abbreviated AUC equations obtained by linear trapezoidal rule were: AUC=4.5 C0+C1+1.5 C2+5 C4 (r2=0.78, APE=5.78+-1.14%) and AUC=5 C0+C1+C2+5 C3 (r2=0.76, APE=6.21+-1.46%).
Document emailed within 1 workday
