Maprotiline in pain-depression
Lindsay, P.G.; Olsen, R.B.
Journal of Clinical Psychiatry 46(6): 226-228
1985
ISSN/ISBN: 0160-6689 PMID: 3888970 Document Number: 242050
A group of 25 patients treated with maprotiline was studied to test the question of second-generation antidepressant effectiveness in chronic pain. Of this group, 18 (72%) responded with a greater than 50% reduction in their pain syndrome. It appears that maprotiline is as effective as earlier antidepressants in the treatment of pain. The enkephalin induction hypothesis is discussed as an explanation for the mechanism of action of antidepressants in chronic pain.