Long-term treatment of arterial hypertension with verapamil
Wigler, I.; Peer, G.; Soferman, G.; Blum, M.; Aviram, A.
International Journal of Clinical Pharmacology Therapy and Toxicology 22(3): 162-166
1984
ISSN/ISBN: 0174-4879 PMID: 6715085 Document Number: 239145
Based on the vasodilator properties of calcium antagonists, verapamil was recently introduced into the treatment of arterial hypertension. The present study was undertaken to examine the long-term efficacy of this drug in mild and moderate hypertension. In 82 patients with uncontrolled primary or renal hypertension, verapamil was used either alone or in combination with other drugs. In six cases verapamil was withdrawn because of side effects. In the remaining patients a normal average blood pressure was achieved within 7.8 +/- 1.2 weeks of treatment with doses not exceeding 400 mg/day. This effect was maintained for up to 4 years of treatment, although tolerance seemed to develop in about 10% of the patients. In view of this good response and minimal side effects, it is concluded that verapamil is an effective addition to the antihypertensive arsenal.