Platelet aggregation abnormalities in arterial occlusive diseases (AOD)
Benner, K.U.; Geeren, M.; Burstedde, V.; Everts, B.
Journal of Medicine 15(1): 23-34
1984
ISSN/ISBN: 0025-7850 PMID: 6593403 Document Number: 239118
Ex vivo and in vitro studies of blood platelets were performed on a total of 70 clinically healthy donors of different age and sex and compared with the results observed in 86 patients suffering from venous thrombotic or arterial occlusive diseases (AOD) of the lower limb using several techniques. Significant thrombocytic hyperfunction present was found both nephelometrically and with the Wu and Hoak method in AOD. The nephelometrical data could be substantiated with the platelet-count-ratio (PCR) technique. All techniques available apparently have serious limitations. Both the Wu and Hoak and the Born methods are incapable of revealing latent and abortive platelet dysfunctions. Pilot studies suggest that the resolution power of the nephelometric device can be augmented when platelet reactivity is increased by a physiological maneuver by maximal body exercise of the subject to be examined immediately before the aggregation test. It is emphasized that adherence to constant experimental conditions is an essential condition for comparative studies on platelet function.