Chemotherapy and immunotherapy of intracranial malignant gliomas
Knerich, R.; Adinolfi, D.; Silvani, V.; Robustelli della Cuna, G.; Spanu, G.; Preti, P.; Rodriguez y Baena, R.
Minerva Medica 75(21): 1333-1340
1984
ISSN/ISBN: 0026-4806 PMID: 6203058 Document Number: 237984
Although in recent years a great attempt has been made in brain tumor chemotherapy, this therapeutic approach appears to be conditioned by a large number of problems such as cell kinetics, tumor growth modalities, and drug delivery. Therefore only a small number of drugs (BCNU, CCNU, streptozotocin, and procarbazine) clearly demonstrate effectiveness against these tumors. Immunotherapy raises the same and other problems. In fact, if immune reaction is quite possible inside the brain, unfortunately current immunostimulant methods are unable to produce significant improvements.