Noninvasive evaluation of endothelial function and arterial mechanics in overweight adolescents
Kumar, V.; Sachdev, H.P.S.; Khalil, A.
Indian Pediatrics 41(11): 1105-1114
2004
ISSN/ISBN: 0019-6061 PMID: 15591660 Document Number: 237779
Objective: To evaluate endothelial function and arterial mechanics in apparently healthy overweight adolescents [India]. Design: Analytical observational study. Setting: Tertiary hospital. Methods: 40 asymptomatic, normotensive and non-smoking adolescents (11 to 18 years old) were evaluated. Of these 20 were overweight or obese as per International Obesity Task Force criteria while 20 were controls. High resolution ultrasonography was performed to measure flow mediated and Glyceryltrinitrate induced dilation in brachial artery, and arterial mechanics in common carotid artery. Results: Overweight adolescents had significantly lower ratio of flow mediated dilation to Glyceryltrinitrate mediated dilation (0.40+or-0.41 versus 0.61+or-0.17; P=0.039). On age and sex adjusted multiple regression analysis, the ratio of flow mediated to Glyceryltrinitrate mediated dilation had a significant negative association with body mass index (P=0.012) and mean skin fold thickness (P=0.011). However, for mean skin fold thickness, flow mediated dilation also had a significant negative association (P=0.027). None of the measures of arterial mechanics were significantly different amongst overweights and controls, or significantly associated with either body mass index or mean skin fold thickness. Conclusions: Endothelial function can be mildly impaired in apparently healthy adolescents who are overweight (assessed by body mass index) or adipose (assessed by skin fold thickness). The use of overweight for screening adolescents likely to develop coronary artery disease is therefore justified. Skin fold thickness is a better indicator than Body Mass Index for predicting endothelial function.