Mortality analysis of HIV-1 infected patients for prioritizing antiretroviral drug therapy
Pathipvanich, P.; Rojanawiwat, A.; Ariyoshi, K.; Miura, T.; Pumpradit, W.; Wongchoosie, S.; Yingseree, P.; Warachit, P.; Sawanpanyalert, P.
Journal of the Medical Association of Thailand 87(8): 951-954
2004
ISSN/ISBN: 0125-2208 PMID: 15471301 Document Number: 2377
Mortality data of patients, classified according to their clinical status and CD4+ cell count status, would be very useful to guide clinicians to prioritizing patients who need antiretroviral drug therapy. In the current study, the authors re-analyzed data derived from a previously published retrospective study of HIV-1-infected individuals at Lampang Hospital in northern Thailand. According to the Cox proportional hazard model, compared to asymptomatic patients with a high CD4+ cell count (> 200 cell/microl), the mortality rate of asymptomatic patients with a medium CD4+ cell count (100-199 cell/microl) did not significantly differ. However, the mortality rate of patients with a CD4+ cell count below 100 cell/microl was at least 16 times higher, regardless of the presence of clinical symptoms. Based on these results, the authors produced a Lampang Hospital guideline of antiretroviral drug use; priority of antiretroviral therapy should, therefore, be given to patients with CD4+ cell count < 100 cell/microl.
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