A study on clinical significance of oncofetal antigen-1 in gynecologic tumors
Takahashi, M.
Nihon Sanka Fujinka Gakkai Zasshi 36(12): 2613-2618
1984
ISSN/ISBN: 0300-9165 PMID: 6520482 Document Number: 237430
To investigate the immune response of patients with gynecologic cancer to a new cancer-related fetal antigen (OFA-1), anti-OFA-1 was titrated by the immune adherence method in these patients. A high prevalence of anti-OFA-1 was observed in a number of different histologic types of tumor; OFA-1 can be highly immunogenic in patients. To identify anti-OFA-1 profiles that correlate with prognosis and to understand the role of anti-OFA-1 behavior in vivo, the anti-OFA-1 response to various gynecologic cancer patients was analyzed in relation to the course of their disease. Cases which had persistently high anti-OFA-1 levels following surgery and those in which anti-OFA-1 titer increased to > 2-fold were free of clinical diseases. In cases in which anti-OFA-1 antibody increased and then dropped gradually, this was followed by clinical recurrence or metastases. Cases without response to OFA-1 were associated with no recurrence. Monitoring anti-OFA-1 in patients could have immediate clinical application in evaluating prognosis.