The influence of hyperbilirubinaemia on malaria-related mortality: an analysis of 1103 patients
Mishra, S.K.; Pati, S.S.; Satpathy, S.K.; Mohanty, S.; Mohapatra, D.N.
Annals of Tropical Medicine and Parasitology 98(6): 555-558
2004
ISSN/ISBN: 0003-4983 PMID: 15324462 DOI: 10.1179/000349804225021389Document Number: 237255
The influence of hyperbilirubinaemia on malaria-related mortality was explored among 1103 cases of acute, Plasmodium falciparum malaria at a referral hospital in Orissa, India. Most (64.3%) of the subjects investigated had >1.2 mg bilirubin/dl serum and were therefore considered hyperbilirubinaemic. Compared with the other patients, those with hyperbilirubinaemia were much more likely to have cerebral malaria (24.1% vs. 9.4%; P<0.0001) or acute renal failure (9.5% vs. 2.3%; P<0.0001), but not severe anaemia (5.9% vs. 4.3%; P<0.22). Mortality was 7.9% among the patients with hyperbilirubinaemia (all the deaths being attributable to cerebral malaria, acute renal failure and/or severe anaemia) but only 1% among the non-hyperbilirubinaemics. There were no deaths, however, among the 506 hyperbilirubinaemics who did not have cerebral malaria, acute renal failure or severe anaemia, even among those with high serum concentrations of bilirubin. It therefore appears that, in acute, Plasmodium falciparum malaria, hyperbilirubinaemia is not in itself a severe complication, and only appears linked with mortality when associated with at least one other complication.