Interferon-gamma production by peripheral blood mononuclear cells from patients with Behçet's syndrome
Bacon, T.H.; Ozbakir, F.; Elms, C.A.; Denman, A.M.
Clinical and Experimental Immunology 57(3): 541-547
1984
ISSN/ISBN: 0009-9104 PMID: 6432387 Document Number: 237016
Interferon-.gamma. (IFN-.gamma.) production by peripheral blood mononuclear cells (MNC) from patients with Behcet's syndrome was compared with production by MNC from control donors. There was no evidence of significant spontaneous production of either IFN-.gamma. or interferon-.alpha. (IFN-.alpha.) by unstimulated MNC from patients or controls, but phytohemagglutinin treatment of MNC induced IFN-.gamma. in both patient and control groups. Significantly higher titers of IFN-.gamma. were produced by MNC from patients with Behcet's syndrome than MNC from patients with other inflammatory diseases (P = 0.005), hospital controls (P = 0.036) or health controls (P = 0.009). No IFN was detected in plasma from patients or controls.