Preservation of the nipple and areola for breast cancer--histopathological study on cancerous involvement of the nipple and areola
Morimoto, T.; Komaki, K.; Yamamoto, H.; Umemoto, A.; Inui, K.; Nishimoto, K.; Sonoo, H.; Harada, K.; Inoue, K.
Nihon Geka Gakkai Zasshi 85(8): 758-762
1984
ISSN/ISBN: 0301-4894 PMID: 6493198 Document Number: 234684
In 141 mastectomy specimens, performed for invasive or non-invasive carcinomas, histopathologic study was performed to assess the extent of nipple-areola involvement by the tumor. In this study, patients were excluded when 1) the tumor was located beneath the areola, 2) nipple and/or areola abnormalities were clinically present. Tumor involvement of the nipple and/or areola was found in 44 of 141 specimens (31%), with intraductal growth in 36 (82%) of 44, stromal invasion in 3 (7%) and ductal & stromal invasion in 5 (11%). Analysis of nipple-areolar involvement with consideration of the different variables indicates that it occurred in association with tumor size, tumor-areola distance and histological type. Such information provides clinically relevant guide lines in decision making for limited breast surgery.