Morphometric analysis of platelets in Bernard-Soulier syndrome: size and configuration in patients and carriers
McGill, M.; Jamieson, G.A.; Drouin, J.; Cho, M.S.; Rock, G.A.
Thrombosis and Haemostasis 52(1): 37-41
1984
ISSN/ISBN: 0340-6245 PMID: 6495263 Document Number: 233995
Quantitative ultrastructural morphometric analysis has been carried out on thin sections of platelets from two Bernard-Soulier sisters and their parents. Measurements were made for the major and minor axes, axial ratios, cross-sectional circumference and cross-sectional area. Platelets were collected either into CPD anticoagulant or directly into glutaraldehyde. The results confirm that Bernard-Soulier platelets are significantly larger than normals (p less than 0.05) in all the parameters mentioned and indicate (I) that the morphology of platelets from Bernard-Soulier patients is affected by the presence of anticoagulant, and (II) a more spherocytic configuration is characteristic of Bernard-Soulier disease both in patients and carriers.