Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates
Sironi, M.; Canegrati, M.A.; Romano, M.; Vecchi, A.; Spreafico, F.
Cancer Treatment Reports 68(4): 643-645
1984
ISSN/ISBN: 0361-5960 PMID: 6713420 Document Number: 233922
A model, employing murine L1210 leukemia to which the artificial determinant TNP was bound in vitro and an anti-DNP antibody-ricin A-chain conjugate, was used to explore the in vivo therapeutic potential of combined immunotoxin-chemotherapy treatment. Under conditions in which immunotoxin and chemotherapy as single therapies had only marginal therapeutic activity, their combined use was markedly effective.