Monotherapy of Pseudomonas aeruginosa septicemia with azlocillin
Godard, J.; Aubertin, J.; Borderon, J.C.; Dureux, J.B.; Motin, J.
Presse Medicale 13(13): 819-821
1984
ISSN/ISBN: 0755-4982 PMID: 6231603 Document Number: 233855
Azlocillin was administered alone to seven patients without malignant or blood disease presenting with septicaemia caused by Pseudomonas aeruginosa. In 6 cases the infection developed after surgery and in 3 of these it was responsible for a state of shock, twice associated with acute anuric renal failure. The minimum inhibitory concentrations of azlocillin varied from 2 to 32 micrograms/ml; 5 strains were resistant to carbenicillin. The minimum inhibitory to minimum bactericidal concentrations ratio, measured on five occasions, was equal to 2. Bacterial eradication was obtained in 6 patients. One patient with multivisceral failure died during treatment and in this case the responsible organism had become resistant to azlocillin.