Ankylosing spondylitis is part of a multifactorial syndrome: hereditary multifocal relapsing inflammation (HEMRI)
Møller, P.; Berg, K.
Clinical Genetics 26(3): 187-194
1984
ISSN/ISBN: 0009-9163 PMID: 6332689 Document Number: 233501
Complex associations between the different subgroups of seronegative arthritis, acute anterior uveitis, psoriasis and inflammatory bowel disease were found in a series of patients and relatives. Different HLA-B antigens were associated with different clinical signs. The results indicated the existence of a multigenic syndrome whose main clinical manifestations are relapsing inflammation at various sites. The genetic factors appeared to be HLA-B27 associated disease susceptibility, predisposition to psoriatic arthropathy, predisposition to early onset familial psoriasis and a probable predisposition to inflammatory bowel disease and its associated arthropathy. The different genetic factors may interact and influence each other's penetrance and expression.