Myocardial infarction and severe thromboembolic complications. as seen in an estrogen-dependent transsexual
Fortin, C.J.; Klein, T.; Messmore, H.L.; O'Connell, J.B.
Archives of Internal Medicine 144(5): 1082-1083
1984
ISSN/ISBN: 0003-9926 PMID: 6324709 Document Number: 232952
An estrogen-dependent genetic-male transsexual had an extensive anterior wall myocardial infarction, despite insignificant coronary artery disease, a subsequent mural thrombosis, and resultant multiple cardioarterial thromboembolic events, despite heparin therapy. With an otherwise lack of cardiac risk factors, the patient was demonstrated to have an antithrombin III deficiency that resolved when conjugated estrogen therapy was withdrawn. Although congenital, plasminogen-activator dysfunction, or heparin-induced etiologies could not be ruled out, we believe this case demonstrated an estrogen-induced-antithrombin III deficiency culminating in thrombotic diathesis. This identifies a previously unrecognized population at risk. Prophylactic and therapeutic considerations are discussed.