Integrated criteria of fine-needle aspiration cytology and radiological imaging for verification of breast cancer in nonpalpable lesions
Sampatanukul, P.; Boonjunwetwat, D.; Thanakit, V.; Pak-Art, P.
Journal of the Medical Association of Thailand 89(2): 236-241
2006
ISSN/ISBN: 0125-2208 PMID: 16579012 Document Number: 2324
Objectives: To evaluate the accuracy of using radiologic, cytologic and integrated radiologic and cytologic criteria in diagnosis of nonpalpable breast lesions.Material and Method: From January 2003 to May 2004, a prospective study of performing fine-needle aspiration biopsy (FNAB) was carried out at King Chulalongkorn Memorial Hospital on female patients with nonpalpable or vaguely palpable lumps that needed ultrasound localization for the direction and depth.Results: There were 162 lesions from 150 patients, consisting of 29 malignant neoplasms (17.9%) and 133 benign lesions (82.1%). Of the 107 classified as subcentimeter focal lesions (< 1 x 1 cm(2) in size), two of radiological malignancy were false and two others were falsely negative by cytology. While the 23 large/ill-defined lesions (> 1.5 x 1.5 cm(2) in size), one hiding malignant lesion adjacent to a prominent intraduct papilloma was missed Two others had falsely negative cytologic diagnosis. The integrated criteria achieved accuracy and sensitivity of 97.5% and 93% compared with the cytology, 96.3% and 82.8% and the better scenario of radiology, 95.7% and 82.8% respectively.Conclusion: The integrated criteria provide the most accuracy, rate and sensitivity rate for detection of malignancy in nonpalpable breast lesions.
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