Use of protein-to-creatinine ratio in a single urine specimen for quantitative estimation of canine proteinuria
White, J.V.; Olivier, N.B.; Reimann, K.; Johnson, C.
Journal of the American Veterinary Medical Association 185(8): 882-885
1984
ISSN/ISBN: 0003-1488 PMID: 6501047 Document Number: 232294
The daily excretion of urinary protein was evaluated in 8 conditioned research dogs and in 10 hospitalized, proteinuric dogs, using 24-hour urine collections. Concurrent with each 24-hour urine collection, a 5- to 10-ml urine specimen was obtained during midday. The ratio of urine protein to urine creatinine concentration was determined from the single urine specimen for each dog. Linear regression analysis was used to calculate the correlation between that ratio and the 24-hour urinary protein loss (mg/kg of body weight). The coefficient of determination was significant (r2 = 0.95, P less than 0.0001). Determination of the protein-to-creatinine ratio in a single urine specimen was found to be a sensitive, rapid, and dependable diagnostic technique for detection and quantitative estimation of proteinuria.