The retinoids in acne
Bushnell, D.E.; Billstein, S.; Schwartz, R.A.; Lambert, W.C.
American Family Physician 29(3): 221-226
1984
ISSN/ISBN: 0002-838X PMID: 6230905 Document Number: 231736
Vitamin A is essential for growth and development, reproduction and vision in humans. Chemical modification of vitamin A has yielded compounds showing therapeutic promise in skin and neoplastic diseases. The medicinal use of retinoids (vitamin A and its derivatives) is limited by the toxicity associated with this group of compounds. One retinoid, 13-cis-retinoic acid, has proved to be quite effective in the treatment of severe recalcitrant cystic acne under conditions in which toxicity is manageable.
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