Endocrine and metabolic mechanisms of the pathological syndrome due to antigens of homologous glial tissue in monkeys

Cupić, D.; Krzalić, L.; Nastić-Mirić, D.; Korneva, E.A.; Shkhinek, E.K.

Biulleten' Eksperimental'noi Biologii i Meditsiny 98(12): 666-668

1984


ISSN/ISBN: 0365-9615
PMID: 6542439
Document Number: 231618
Monkeys (Macaca mulatta) of both sexes repeatedly immunized with a complex of glial antigens of the homologous brain demonstrated abnormalities of hormonal functions after 1 to 5 weeks. These abnormalities were marked by a decrease in the total serum tyroxine (after 1 week) and a rise in the concentration of 11-hydroxycorticosteroids (11-OHCS) that occurred after 5 weeks. The changes in tyroxine level were more stable than those in the concentration of 11-OHCS. The immunized animals manifested changes in the disc electrophoregram of the serum. Application of stress resulted in a consistent elevation of the concentration of 11-OHCS and in temporary changes in the number and intensity of individual fractions of serum proteins. The fractional composition of serum proteins was different in control and experimental monkeys.

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