A long-term study of experimental duodenogastric reflux on the vagotomized stomach in dogs
Mosimann, F.; Burri, B.; Diserens, H.; Fontolliet, C.; Loup, P.W.; Mirkovitch, V.; Mosimann, R.
Scandinavian Journal of Gastroenterology. Suppl 92: 136-137
1984
ISSN/ISBN: 0085-5928 PMID: 6588500 Document Number: 230929
The possibility has been explored in dogs that the effects of chronic enteral reflux on the gastric mucosa may be modified by highly selective vagotomy (HSV). In both the innervated and the vagotomized stomachs, Roux-en-Y duodenogastrostomy induced mucosal hyperaemia and foveolar hyperplasia; the mucosa regained normal morphology after the elimination of reflux. Duodenogastrostomy without HSV did not influence basal serum gastrin but resulted in a significant increase in mucosal histamine. After duodenogastrostomy with HSV basal serum gastrin decreased significantly and mucosal histamine was not affected. It is concluded that foveolar hyperplasia is a reversible reaction of the mucosa to potentially damaging agents like enteral contents. It is also suggested that the combination of chronic enterogastric reflux, abnormal gastrointestinal motility and HSV might have an inhibitory effect on gastrin release.