Anaplastic transformation of well differentiated carcinoma of the thyroid
Maeda, S.; Souno, K.; Sugiyama, T.
Gan no Rinsho. Japan Journal of Cancer Clinics 30(11): 1407-1411
1984
ISSN/ISBN: 0021-4949 PMID: 6094883 Document Number: 230879
Four cases of thyroid cancer with anaplastic transformation are reported. The anaplastic transformed cancers were found as a metastatic lesion 3-37 years after the resection of well-differentiated thyroid cancers. In one case, anaplastic cancer was mixed with well-differentiated cancer in an old metastatic focus but not present in the partially removed hyalinized primary lesion. The role of radiation therapy in anaplastic transformation was discussed.