Requirements for suppressor T cell activation
Usui, M.; Aoki, I.; Sunshine, G.H.; Dorf, M.E.
Journal of Immunology 133(3): 1137-1141
1984
ISSN/ISBN: 0022-1767 PMID: 6205067 Document Number: 230486
Third-order (Ts3) . The mechanism of this TsF2-mediated triggering event was analyzed. TsF2-mediated suppression is genetically restricted by genes in the I-J and Igh-V regions. The target of the I-J restrictions is a firmly adherent accessory cell, which appears to express I-J-related determinats. These accessory cells are sensitive to cyclophosphamide treatment and 500 R irradiation. In contrast, the target of the Igh-V restriction of TsF2 appears to be the Ts3 cell, which carries antigen-specific, idiotype-related receptors. The mechanism of suppressor cell activation appears to involve 2 stages, presentation of I-J-restricted TsF2 by I-J-compatible presenting cells and a 2nd step involving idiotype-anti-idiotype interactions between TsF2 and the Ts3 cell. I-J compatibility is not required with the accessory cell for Ts3 activation. The anti-idiotypic determinants expressed on TsF2 can probably serve as an internal image of antigen, thereby permitting specific targeting of the factor.