Analysis of clinical specimens by hybridisation with probe containing repetitive DNA from Plasmodium falciparum. A novel approach to malaria diagnosis
Franzén, L.; Westin, G.; Shabo, R.; Aslund, L.; Perlmann, H.; Persson, T.; Wigzell, H.; Pettersson, U.
Lancet 1(8376): 525-528
1984
ISSN/ISBN: 0140-6736 PMID: 6142251 Document Number: 230434
The capacity of a DNA probe containing cloned repetitive sequences from P. falciparum to identify malaria-infected blood sampels was tested with a spot hybridization assay. Parasitemia levels of 0.001% could be detected in 50 .mu.l blood from patients. The probe correctly diagnosed P. falciparum infection in patients from different continents and appeared to be specific for P. falciparum since it did not crossreact with 3 other Plasmodium spp. tested.
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