Heterotopic ossification and HLA antigens
Garland, D.E.; Alday, B.; Venos, K.G.
Archives of Physical Medicine and Rehabilitation 65(9): 531-532
1984
ISSN/ISBN: 0003-9993 PMID: 6433856 Document Number: 230089
Thirty patients with neurogenic (nontraumatic) heterotopic ossification following spinal cord injury in 20 and head injury in 10, were comprehensively screened for HLA antigens. The frequencies of 68 HLA-A, -B and -C antigens were examined. The HLA-A2 locus was present in 18 patients (60%) as compared to the phenotypically adjusted normal of 48.4% and was not statistically significant at the 0.05 level. No statistically significant increased frequency of the HLS-B18 or HLA-B27 antigens was detected. A positive correlation does not exist between the HLA antigen system and patient susceptibility to heterotopic ossification following head injury or spinal cord injury.