Release of cholecystokinin in response to food and intraduodenal fat in pigs, dogs and man
Lilja, P.; Wiener, I.; Inoue, K.; Fried, G.M.; Greeley, G.H.; Thompson, J.C.
Surgery Gynecology and Obstetrics 159(6): 557-561
1984
ISSN/ISBN: 0039-6087 PMID: 6095475 Document Number: 229955
The present study was done to compare endogenous cholecystokinin-33 release in response to physiologic stimuli (meal, fat) in pigs, dogs and man. Plasma levels of cholecystokinin-33 were monitored using a radioimmunoassay for cholecystokinin which detects only cholecystokinin-33 and cholecystokinin-39. Ingestion of a meal caused release of cholecystokinin-33 within five, 20 and 120 minutes in man, pigs and dogs, respectively. Intraduodenal administration of corn oil resulted in a significant release of cholecystokinin-33 within 20 minutes in dogs, pigs and man.