Postoperative insulin resistance of lipolysis and ketogenesis using the glucose clamp technic
Jauch, K.W.; Günther, B.; Wicklmayr, M.; Teichmann, R.; Hartl, W.; Dietze, G.
Infusionstherapie und Klinische Ernahrung 11(5): 271-274
1984
ISSN/ISBN: 0378-0791 PMID: 6392097 Document Number: 229926
In seven healthy patients we studied the influence of various doses of insulin on the substrate concentration of free fatty acids and ketone bodies on the first day after major abdominal surgery by the glucose clamp technique. Insulin was infused at a rate of 0.2 and 1.0 mU/kg bw.min for ninety minutes and thus insulin concentrations were raised twice and seven times above the basal value. Already the minimal infusion of 0.2 mU insulin/kg.bw.min lead to a significant decrease of free fatty acids and ketone bodies. Our results show that even in postoperative stress the lipolysis of adipose tissue can be reduced by minimal insulin doses.