Anti-angina effect of gallopamil in comparison with another calcium antagonist and a placebo
Hopf, R.; Drews, H.; Kaltenbach, M.
Zeitschrift für Kardiologie 73(9): 578-585
1984
ISSN/ISBN: 0300-5860 PMID: 6391005 Document Number: 229039
In 12 male patients with angiographically confirmed coronary heart disease and stable angina the antianginal effects of 50 mg Gallopamil have been studied in comparison with 10 mg Nifedipine and placebo. The study has been carried out using a double-blind cross-over protocol with standardized exercise stress tests. Patients underwent 5 exercise step tests, without any medication and 120 minutes after randomized drug administration (placebo, placebo, Gallopamil, Nifedipine). Both Gallopamil and Nifedipine had good antianginal effects. Following 50 mg Gallopamil, ischemic ST-depression was reduced by 45% compared to placebo and by 50% compared to ergometry without any medication. The reduction of ST-depression after 10 mg Nifedipine was 26% compared to placebo and 31% compared to a drug-free exercise test. Due to the negative chronotropic effects, Gallopamil led to a slight but significant reduction of heart rate at rest and during exercise of about 5%. In contrast, after Nifedipine administration, a reflex-mediated increase in heart rate could be seen. In normotensive patients both channel-blocking agents showed a slight reduction of arterial blood pressure. The results indicate a considerable antianginal effect of a single oral dose of 50 mg Gallopamil. In comparison to 10 mg Nifedipine this effect is more pronounced.