Hyper IgE syndrome: four case report
Pigatto, P.D.; Polenghi, M.M.; Altomare, G.F.; Brugo, A.M.; Tadini, G.L.; Morelli, M.
Bollettino dell'Istituto Sieroterapico Milanese 63(4): 378-382
1984
ISSN/ISBN: 0021-2547 PMID: 6549138 Document Number: 229014
Patients with hyper IgE syndrome (HIES) have varying degree of immunological unbalance that account for deficiency of total T and OKT8 lymphocytes. To investigate the role of immunostimulating drugs in HIES, thymostimulin (TP1) and levamisole were given in highly controlled groups of patients after a wash out period with disodium-chromoglycate (DSCG). Both drugs do not modify clinical picture whereas they do modulate some laboratory parameters as T lymphocyte total number, IgE plasmatic concentration, neutrophil chemotaxis. Furthermore TP1 had a worsening clinical effect in 3 of our patients. In our opinion we feel that the therapies proposed and employed so far for this rare disease must be critically analyzed.