Testicular function after renal transplantation: comparison of Cyclosporin a with azathioprine and prednisone combination regimes
Handelsman, D.J.; McDowell, I.F.; Caterson, I.D.; Tiller, D.J.; Hall, B.M.; Turtle, J.R.
Clinical Nephrology 22(3): 144-148
1984
ISSN/ISBN: 0301-0430 PMID: 6386252 Document Number: 227587
Testicular function was assessed in 24 men after renal transplantation who were on either Cyclosporin A (CSA) (8 men) or a combination of azathioprine and prednisone (AZP) (16 men) as immunosuppressive therapy. The different regimes were not associated with any differences in clinical or hormonal (LH, FSH, prolactin, testosterone, estradiol) indices of testicular function although adrenal androgen (dehydroepiandrosterone sulphate) was suppressed in prednisone-treated men. Overall, however, poor graft function was associated with abnormal testicular function. Renal allograft function rather than immunosuppressive regime was the major determinant of gonadal function.