N-acetyltransferase activity during growth of the transplantable Pliss lymphosarcoma and during pregnancy in rats
Riazanov, E.M.; Aleksandrov, V.A.; Bulovskaia, A.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 98(7): 68-70
1984
ISSN/ISBN: 0365-9615 PMID: 6547867 Document Number: 227022
Study of the distribution of female noninbred rats according to N-acetyltransferase activity has permitted the conclusion to be derived that the animals may have a "slow", "intermediate" and "fast" phenotype of acetylation. It was discovered that the rate of N-acetyltransferase activity increased 1.5-2-fold on days 12 and 15 after transplantation of Pliss's lymphosarcoma. The time course of changes in N-acetyltransferase activity was characterized by individual features. The pattern of changes in N-acetyltransferase activity in pregnancy was dependent on the initial acetylation phenotype: in animals with a "slow" and "intermediate" phenotype of acetylation, the activity ascended by the 21st day of pregnancy, whereas in animals with a "fast" phenotype of acetylation, it declined.