Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda

Kagulire, S.C.; Opendi, P.; Stamper, P.D.; Nakavuma, J.L.; Mills, L.A.; Makumbi, F.; Gray, R.H.; Shott, J.P.; Serwadda, D.; Reynolds, S.J.; Kagulire, S.C; Opendi, P; Stamper, P.D; Nakavuma, J.L; Mills, L.A; Makumbi, F; Gray, R.H; Shott, J.P; Serwadda, D; Reynolds, S.J

doi:10.1258/ijsa.2009.009352

Home

>

Node

>

Subnode

Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda

Kagulire, S.C.; Opendi, P.; Stamper, P.D.; Nakavuma, J.L.; Mills, L.A.; Makumbi, F.; Gray, R.H.; Shott, J.P.; Serwadda, D.; Reynolds, S.J.

International Journal of Std and Aids 22(6): 308-309

2011

ISSN/ISBN: 1758-1052

PMID: 21680664

DOI: 10.1258/ijsa.2009.009352

Document Number: 226790

The performance characteristics of HIV rapid diagnostic tests (RDTs) vary by test and by population. We assessed five commercial RDTs in Uganda where all but one RDT (Determine; Abbott Laboratories, Germany) performed close to manufacturer's expectations. Determine had low specificity (85.2%, positive predictive value 67.3%) due to false-positive results with weak-positive bands. Properly trained staff, good quality control programmes and validation of RDTs with laboratories having confirmatory testing capacity may be warranted to assure accuracy in each setting.