Microflora study and the pharmacokinetic characteristics of gentamycin in children with mucoviscidosis
Skala, L.Z.; Klimova, V.S.; Shabalova, L.A.
Antibiotiki 29(1): 49-51
1984
ISSN/ISBN: 0003-5637 PMID: 6696404 Document Number: 226295
P. aeruginosa and Staphylococcus were isolated respectively from 46.7 and 30.9 per cent of the children with mucoviscidosis. Proteus, Klebsiella and hemophilic bacilli were isolated from 11.2, 2.8 and 2.8 per cent of the patients respectively. All the isolates of Proteus, 95.8 per sent of the staphylococcal strains and 16.7 per cent of the P. aeruginosa strains were highly sensitive to gentamicin. No gentamicin resistant strains were detected. The studies on the gentamicin pharmacokinetics showed that the maximum levels of the drug in the blood and sputum of the children treated with the antibiotic injected intramuscularly in doses of 1.2 and 2-2.5 mg/kg were attained in 1 hour. The concentration of gentamicin in the sputum amounted to 60-80 per cent of its concentration in the blood serum. Within 11 hours the antibiotic sputum levels were higher than the MIC for the organisms sensitive to gentamicin. After a single endobronchial administration of the drug it was detected in the sputum for 6 days in concentrations exceeding the MIC for the moderately sensitive strains.