Secretory diarrhea with islet cell hyperplasia and increased immunohistochemical reactivity to serotonin
Nishiyama, R.H.; Thompson, N.W.; Lloyd, R.; Augur, N.A.
Surgery 96(6): 1038-1044
1984
ISSN/ISBN: 0039-6060 PMID: 6095478 Document Number: 225422
Two patients with secretory diarrhea and signs and symptoms consistent with the Verner-Morrison syndrome and islet cell hyperplasia are described. Both patients responded well to subtotal pancreatectomies. The morphologic changes in the pancreata were characterized by proliferation of islets associated with periductal and interstitial fibrosis. Immunohistochemical stains demonstrated increased staining for serotonin in islet cells. A few islet cells also stained for vasoactive intestinal polypeptide. The significance of these results is discussed.