Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
Pennica, D.; Nedwin, G.E.; Hayflick, J.S.; Seeburg, P.H.; Derynck, R.; Palladino, M.A.; Kohr, W.J.; Aggarwal, B.B.; Goeddel, D.V.
Nature 312(5996): 724-729
1984
ISSN/ISBN: 0028-0836 PMID: 6392892 Document Number: 225182
Human tumor necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumor necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the hemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.
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