Experimental assessment of selected antimotion drugs
Matsnev, E.I.; Bodo, D.
Aviation Space and Environmental Medicine 55(4): 281-286
1984
ISSN/ISBN: 0095-6562 PMID: 6732678 Document Number: 225054
Space motion sickness (SMS) has been a perplexing problem in both the Soviet and U.S. manned space programs. Both the sensory conflict theory (neuronal signal mismatch) and the cephalad fluid shift concept explain the mechanism. This paper reviews the mechanism of action of various drugs that primarily affect brain blood flow or brain metabolism. In particular, Cavinton (apovincamic acid ethyl ester) has been used successfully in offsetting SMS in experimental test subjects.