Synthesis of LDL-apoproteins in D-galactosamine-induced hepatitis in rats
Nadkarni, G.D.; Pestonjamasp, K.N.
Indian Journal of Biochemistry and Biophysics 21(1): 57-58
1984
ISSN/ISBN: 0301-1208 PMID: 6490058 Document Number: 223586
A single i.p. injection of D-(+) galactosamine (330 mg/kg) caused profound alterations in total lipid and low density lipoprotein(LDL)-apoprotein metabolism in adult rats. There was 35% reduction in serum total lipids and 54% elevation in liver total lipids after 25 h. These perturbations could be partly explained on the basis of 42% inhibition of synthesis of LDL-apoproteins in the liver.
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