A call for caution in the use of aminoglutethimide: negative interactions with dexamethasone and beta blocker treatment
Halpern, J.; Catane, R.; Baerwald, H.
Journal of Medicine 15(1): 59-63
1984
ISSN/ISBN: 0025-7850 PMID: 6149250 Document Number: 223107
Two case reports are described, both breast carcinoma patients with metastatic disease. One of the patients had a dexamethasone dependent brain metastatic condition. The second patient suffered from high blood pressure, which was controlled with beta-blocker drugs. Both patients developed severe complications when treated with aminoglutethimide as a cancer hormonal therapy. The case reports are described and possible drug interaction mechanisms are discussed.